PredatorsKnown predators of ''S. officinalis'' include large fish and whales.
In the wild, ''S. officinalis'' is known to prey upon a wide variety of animals. These include: bony fish, copepods, crustaceans , decapod cephalopods, gastropods, lamellibranches, nemerteans, octopods, ostracods, polychaetes, and pteropods.
A 2008 study on ''S. officinalis'' revealed that cuttlefish embryos, if visually exposed to a certain species of prey , will hunt primarily for that prey in later life. ''S. officinalis'' usually prefer shrimp to crabs, but when the embryos were exposed to crabs and the embryos had hatched, the young cuttlefish switched preferences and proceeded to hunt the crabs more often than the shrimp.
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